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M. Margaret Knudson, M.D., FACS

M. Margaret Knudson, M.D., FACS

Professor of Surgery,
Division of General Surgery
Medical Director for the Military Health System (MHS) Strategic-ACS Partnership


Contact Information

Campus Box 0807
University of California, San Francisco
San Francisco, CA 94143-0807
(415) 206-8673 Appointments
(415) 206-4622 Office
(415) 206-5484 Fax
Peggy.Knudson@ucsf.edu

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  • University of Dayton, B.S., 1972
  • University of Michigan Medical School, M.D., 1976
  • Beth Israel Hospital, Harvard Medical School, Intern Surgery, 1976-1977
  • Beth Israel Hospital, Harvard Medical School, Resident Surgery, 1977-1979
  • University of Michigan Medical School, Resident, Surgery, 1979-1981
  • University of Michigan Medical School, Chief Resident, Surgery, 1981-1982
  • Stanford University School of Medicine, Fellow, Pediatric Surgery, 1982-1983
  • American Board of Surgery, 1983
  • American Board of Surgery, Surgical Critical Care, 1988
  • Breast Surgery
  • General Surgery
  • Pediatric Trauma Surgery
  • Trauma Surgery
  • Ultrasound
  • Head Injuries
  • Injury Prevention
  • Pediatric Trauma
  • Resuscitation
  • Simulation
  • Trauma
  • Ultrasound
  • Venous Thromboembolism

 M. Margaret "Peggy" Knudson, MD, FACS attended medical school and completed her general surgical residency at the University of Michigan in Ann Arbor. After a fellowship in pediatric surgery at Stanford University, she became involved with the development of trauma systems in California, with a special interest in pediatric trauma. After serving as the Associate Trauma Director at Stanford Medical Center, she joined the teaching faculty at the University of California, San Francisco in 1989. 

Dr. Knudson has been on the front lines of treating trauma vitctims in major disasters including the 2010 Haitian earthquake and the crash of Asiana Airlines Flight 214 in San Francisco in July 2013. She has also served as visiting surgeon  at both Landstuhl Regional Medical Center in Germany and Balad Air Force Hospital in Iraq, treating soldiers injured on the battleflied. In 2012, Dr. Knudson was named to  U.S. News "America's Top Doctors," which reflects her inclusion as in the top 1% of physicians in the U.S. for one of her specialties. And in 2014 Dr. Knudson joined the Division of Member Services of the American College of Surgeons (ACS) and was named Medical Director for the Military Health System (MHS) Strategic-ACS Partnership. 

Dr. Knudson also serves as the Vice Chair of the Committee on Trauma, a member of the Executive Committee, American College of Surgeons Committee on Trauma, Board of Managers, American Association for the Surgery of Trauma, on the editorial board of the Journal of Trauma, and as the Chair of the Western Trauma Association's Multi-center Trials Committee. Her major areas of research include simulation training for medical personnel, the prevention of thromboembolic complications in trauma patients, the use of ultrasound in trauma evaluation, resuscitation following hemorrhagic shock, and injury prevention.

Dr. Knudson is involved in a number of projects related to injury and injury prevention: 

  • Resuscitation following Traumatic Brain Injury (Laboratory Study): In a controlled model of traumatic brain injury, the research group is using tissue oxygen probes placed at various locations to better define the brain injury and the effects of ventilation, oxygenation, hemorrhage, and resuscitation on tissue oxygen and capillary metabolism (Lactate/pyruvate/glutamate) following brain injury. 
  • A Comparison of Muscle Lactate Levels with Tissue Oxygen and Metabolism (Laboratory Study): In a small animal model, the research group is comparing serum and tissue lactate levels with other markers (tissue oxygen, bicarbonate, pyruvate) in order to better define the role of lactate as a measure of resuscitation. They are also measuring lactate levels following shock and resuscitation with fluids and various vasoactive agents.
  • Brain Tissue Oxygen Monitoring and Microdialysis Following Severe Traumatic Brain Injury (Clinical Study): Patients with severe brain injury who require ICP monitors are also being monitored with brain oxygen ad microdialysis probes in order to better define their brain injury and response to interventions.
  • Muscle Oxygen Monitoring in Critically Ill Patients (Clinical Study): Tissue oxygen levels measured in the muscle of critically ill trauma patients may be used to help guide resuscitation. The research group is comparing two methods of measuring tissue oxygen (direct probes versus near infra-red techniques) and correlating these measurements with microdialysis data as well as standard variable used to measure resuscitation (blood pressure, pulse, serum bicarbonate levels etc).
  • Posttraumatic Stress Disorder in Injured Children (Clinical Study): Injured children are particularly vulnerable to the development of PTSD. In a prospective study being conducted at Children's Hospital, Oakland, the research group is following children for up to one year post injury for the development of PTSD and comparing interventions designed to lessen these symptoms.
  • Use of ultrasound in patients with Solid Organ Injuries managed nonoperatively: (Clinical study) Using ultrasound, The research group is attempting to define the grade of liver/spleen/ or renal injuries resulting from blunt trauma and following these patients with serial ultrasound exams for progression of their injury, need for operative intervention based on the amount of hemorrhage, and the development of complications associated with non-operative management.
  • Prevention Research and Activities: Through the Injury Center, the research group is involved in a wide range of prevention projects that include pedestrian crashes, violent injuries, pediatric trauma, advocacy, and the development of educational programs in injury prevention for surgeons, medical students, and elementary students.
  • Posttraumatic Thromboembolism: (Analytical Study): Using the National Trauma Data Base, the research group is developing a report on the current incidence of DVT/PE in the United States following injury, describing risk factors, and analyzing the effectiveness of prevention strategies.
  • Simulation and Trauma: (Clinical Study): The research group is designing clinical scenarios that can be utilized in simulation in order to prepare senior surgical residents for their rotation on the trauma service. They hopes to validate the use of simulation for this purpose.
  • Outcome following isolated, mild traumatic brain injury: (Clinical Study) As part of a multi-institutional study, the research group is prospectively following patients with isolated brain injuries for their functional outcomes for a period of one year, and comparing outcomes in elderly versus younger patients.
Most recent publications from a total of 94
  1. Learn PA, Mullen MJ, Saldinger PF, Kreishman P, Cordts PR, Ko CY, Knudson MM, Elster EA. A Collaborative To Evaluate And Improve The Quality Of Surgical Care Delivered By The Military Health System. Health Aff (Millwood). 2019 Aug; 38(8):1313-1320. View in PubMed
  2. Holt D, Copeland A, Knudson MM, Elster E. Commentary to Military Medicine and the Academic Surgery Gender Gap. Mil Med. 2019 Jun 26. View in PubMed
  3. Knudson MM. CARING FOR ALL: THE 2019 WTA PAINT THE CEILING LECTURE. J Trauma Acute Care Surg. 2019 Apr 01. View in PubMed
  4. Knudson MM, Elster EA, Bailey JA, Woodson J. Military Health System Strategic Partnership with the American College of Surgeons. J Am Coll Surg. 2018 Aug; 227(2):296-297. View in PubMed
  5. Knudson MM, Elster EA, Bailey JA, Johannigman JA, Bailey PV, Schwab CW, Kirk GG, Woodson JA. Military-Civilian Partnerships in Training, Sustaining, Recruitment, Retention, and Readiness: Proceedings from an Exploratory First-Steps Meeting. J Am Coll Surg. 2018 Aug; 227(2):284-292. View in PubMed
  6. Loja MN, Sammann A, DuBose J, Li CS, Liu Y, Savage S, Scalea T, Holcomb JB, Rasmussen TE, Knudson MM. The mangled extremity score and amputation: Time for a revision. J Trauma Acute Care Surg. 2017 03; 82(3):518-523. View in PubMed
  7. Knudson MM. When peace breaks out: The 42nd American Association for the Surgery of Trauma Fitts Oration. J Trauma Acute Care Surg. 2017 01; 82(1):10-17. View in PubMed
  8. Price MA, Beilman GJ, Fabian TC, Hoyt DB, Jurkovich GJ, Knudson MM, MacKenzie EJ, Marshall VS, Overton KE, Peitzman AB, Phillips MJ, Pruitt BA, Smith SL, Stewart RM, Jenkins DH. The National Trauma Institute: Lessons learned in the funding and conduct of 16 trauma research studies. J Trauma Acute Care Surg. 2016 09; 81(3):548-54. View in PubMed
  9. Campion EM, Juillard C, Knudson MM, Dicker R, Cohen MJ, Mackersie R, Campbell AR, Callcut RA. Reconsidering the Resources Needed for Multiple Casualty Events: Lessons Learned From the Crash of Asiana Airlines Flight 214. JAMA Surg. 2016 06 01; 151(6):512-7. View in PubMed
  10. Shackford SR, Cipolle MD, Badiee J, Mosby DL, Knudson MM, Lewis PR, McDonald VS, Olson EJ, Thompson KA, Van Gent JM, Zander AL. Determining the magnitude of surveillance bias in the assessment of lower extremity deep venous thrombosis: A prospective observational study of two centers. J Trauma Acute Care Surg. 2016 May; 80(5):734-9; discussion 740-1. View in PubMed
  11. View All Publications
Publications provided by UCSF Profiles, powered by CTSI at UCSF. View profile of M. Margaret Knudson, M.D., FACS
Please note: UCSF Profiles publications are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact CTSI for help.

 

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